Single Nucleotide Polymorphism Analysis in Application to Fine Gene Mapping

...........................................................................................ii Acknowledgments...............................................................................iii List of figures and tables.........................................................................v Introduction........................................................................................1 Thesis objectives................................................................................13 Part I: Investigation of the effect of transition to transversion ratio Methods..........................................................................................14 Results............................................................................................28 Discussion.......................................................................................38 Part II: Application of SNPs in fine gene mapping Introduction......................................................................................41 Methods..........................................................................................45 Results............................................................................................50 Discussion.......................................................................................56 Bibliography.....................................................................................60 Appendices ......................................................................................64